Patent families

1) WO2021080427A1: CHIMERIC POLYPEPTIDE FOR REGULATING IMMUNE CELLS

2) WO2023177296A1: Zinc finger degron sequences

3) WO2024117904A1: Receptor- and drug-dependent regulated on-site production of biologicals.

4) WO2025248464A3: Loop reinforcement expression system for improved cell therapy products.

Papers

1) CRASH-IT switch enables reversible and dose-dependent control of TCR and CAR T-cell function. Cancer Immunology Research

2) Multimodular Optimization of Chemically Regulated T Cell Switches Demonstrates Flexible and Interchangeable Nature of Immune Cell Signaling Domains. Human Gene Therapy

3) Safety switches for adoptive cell therapy. Current Opinion in Immunology